吕丹

电话：(010)-8280 5807 

Email：taotao@bjmu.edu.cn

js3845金沙线路研究员，博士生导师。国家“优青”获得者。中国免疫学会青年工作委员会委员。2006年本科毕业于中国医科大学临床医学专业（87K），2011年毕业于js3845金沙线路免疫学系，获得博士学位。先后在美国Oklahoma Medical Research Foundation 以及北京大学做博士后。2018年正式加入北京大学系统生物医学研究所。

主要研究方向：抗病毒与抗肿瘤免疫。先后主持包括国自然“优青”“面上”在内的多项国家级课题项目，并以第一作者或通讯作者身份在 Nature Immunology  （  2020  ，  2015  ） ,  Advanced Materials   （  2022  ）  ,   Nature communications  （  2021  ） ， EMBO reports  （  2021  ），  Nano Research (2020) 等杂志发表文章，获得三项国家授权发明专利。目前正深入研究肿瘤和病毒免疫逃逸的发生机制，开发新型抗病毒和抗肿瘤纳米药物。

代表性论著：

(1) Sun Y^#, Gong L^#, Yin Y, Zhang L, Sun Q, Feng K, Cui Y, Zhang Q, Zhang X, Deng X, You F*, Lu D*, Lin Z*. A gradient pH-sensitive polymer-based antiviral strategy via viroporin-induced membrane acidification.  Adv Mater. 2022 Feb 28:e2109580.

(2) Dan Lu^#, Liu Liang^#, Sun Yizhe, Song Jia, Yin Qi, Zhang Guangze, Qi Fang, Hu Zixi, Yang Zeliang, Zhou Ze, Hu Ying, Zhang Lianhai, Ji Jiafu, Zhao Xuyang, Jin Yan, McNutt MA, Yin Yuxin.  The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity .  Nat Immunol. 2020 Mar;21(3):287-297. PMID: 31932812.

(3) Sun Y^#, Lu D^#&*, Yin Y, Song J, Liu Y, Hao W, Qi F, Zhang G, Zhang X, Liu L, Lin Z, Liang H, Zhao X, Jin Y, Yin Y*.  PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer.   Nat Commun. 2021 Aug 26;12(1):5147.

(4) Song J^#, Liu T^#, Yin Y, Zhao W, Lin Z, Yin Y*, Lu D*, You F*.  The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity .  EMBO Rep . 2021 Feb 3;22(2):e51162.

(5) Sun Y^#, Yin Y, Gong L, Liang Z, Zhu C, Ren C, Zheng N, Zhang Q, Liu H, Liu W, You F, Lu D*, Lin Z*.  Manganese nanodepot augments host immune response against coronavirus .  Nano Res. 2020 Dec 29:1-13.

(6) Zhu C^#, Ma Q, Gong L, Di S, Gong J, Wang Y, Xiao S, Zhang L, Zhang Q, Fu JJ*, Lu D*, Lin Z*.  Manganese-based multifunctional nanoplatform for dual-modal imaging and synergistic therapy of breast cancer .  Acta Biomater. 2022 Jan 15:S1742-7061(22)00019-8.

(7) Lu D^#, Song J^#, Sun Y, Qi F, Liu L, Jin Y, McNutt MA, Yin Y*.  Mutations of deubiquitinase OTUD1 are associated with autoimmune disorders.  J Autoimmun . 2018 Aug 9; pii: S0896-8411(18)30333-0.

(8) Lu D^#, Liu L^#, Ji X, Gao Y, Chen X, Liu Y, Liu Y, Zhao X, Li Y, Li Y, Jin Y, Zhang Y, McNutt MA, Yin Y*.  The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation.  Nat Immunol. 2015 Dec; 16(12):1263-73.

(9) Lu D^#, Dong D^#, Zhou Y, Lu M, Pang XW, Li Y, Tian XJ, Zhang Y*, Zhang J*. The tumor-suppressive function o f UNC5D and its repressed expression in renal cell carcinoma. Clin Cancer Res. 2013 Jun 1; 19(11):2883-92.

(10) Lu D^#, Zhao W^#, Dong D, Qian XP, Zhang Y, Tian XJ*, Zhang J*.  Genetic and epigenetic control of UNC5C expression in human renal cell carcinoma.  Eur J Cancer. 2011 Sep; 47(13):2068-76.