夏朋延 研究员

       联系方式：

　　办公地址：科技楼北楼B602-5

 Email: xiap@bjmu.edu.cn

研究方向： 1．发现新的模式识别受体、鉴定新的特征性病原分子； 2．探索NLRP3炎症小体的活化机制及其在肠炎、皮肤性炎症中的作用。

主要学习及工作经历： 2004年–2008年于武汉大学生命科学学院获得理学学士学位；2008–2014于中国科学院大学获得生物化学与分子生物学理学博士学位。2014年起在中国科学院生物物理研究所从事博士后研究。2018年12月加入js3845金沙线路免疫学系，担任研究员、博士生导师。

基金申请：2019年获国自然优秀青年基金资助

通讯作者研究论文：

1. Zhu F, Ma J, Li W, Liu Q, Qin X, Qian Y, Wang C, Zhang Y, Li Y, Jiang D, Wang S*, Xia P*. The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome. Immunity. 2023; 56: 753-767.

2. Zhang X, Yu D, Wu D, Gao X, Shao F, Zhao M, Wang J, Ma J, Wang W, Qin X, Chen Y*, Xia P*, Wang S*. Tissue-resident Lachnospiraceae family bacteria protect against colorectal carcinogenesis by promoting tumor immune surveillance. Cell Host Microbe. 2023. 31, 1-15.

3. Zhu F, Yu D, Qin X, Qian Y, Ma J, Li W, Liu Q, Wang C, Zhang Y, Li Y, Jiang D, Wang S*, Xia P*. The neuropeptide CGRP enters the macrophage cytosol to suppress the NLRP3 inflammasome during pulmonary infection. Cell Mol Immunol 2023; 10.1038/s41423-022-00968-w

4. Liu Q, Li W, Qian Y, Wang C, Xia P*. AA467197 controls the hyperactivation of the NLRP3 inflammasome during infection. The Innovation Life. 2023; 1(1): 100012.

5. Zhao M, Shao F, Yu D, Zhang J, Liu Z, Ma J, Xia P*, Wang S*. Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis. Nat Commun 2022; 13:7600.

6. Ma J, Zhu F, Zhao M, Shao F, Yu D, Ma J, Zhang X, Li W, Qian Y, Zhang Y, Jiang D, Wang S*, Xia P*. SARS-CoV-2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage. EMBO J 2021; e108249.

第一作者研究论文：

7. Xia P, Wang S, Ye B, Du Y, Li C, Xiong Z, Qu Y, Fan Z. Circular RNA cia-cGAS protects dormant hematopoietic stem cells from cGAS-mediated exhaustion. Immunity 2018; 48: 688-701 e687.

8. Xia P, Wang S, Xiong Z, Zhu X, Ye B, Du Y, Meng S, Qu Y, Liu J, Gao G, Tian Y, Fan Z. The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity. Nat. Immunol. 2018; 19: 141-150.

9. Xia P, Ye B, Wang S, Zhu X, Du Y, Xiong Z, Tian Y, Fan Z. Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity. Nat. Immunol. 2016; 17: 369-378. (IF: 21.8)

10. Xia P, Wang S, Ye B, Du Y, Huang G, Zhu P, Fan Z. Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection. Nat. Immunol. 2015; 16: 366-375. (IF: 21.8)

受邀请综述及书籍：

1. Xia P, Wang S, Fan Z. DNA sensor cGAS mediates immune recognition. Protein & Cell 2016; 7: 777-791.

2. Xia P, Wang S, Fan Z. Research progress on autophagy and immunity. Chinese Bulletin of Life Sciences 2016; 28: 208-215..

3. Wang S, Xia P, Rehm M, Fan Z. Autophagy and cell reprogramming. Cell. Mol. Life Sci. 2015; 72: 1699-1713.

4. Xia P, Wang S, Fan Z. Chapter 24: Progress on autophagy and immunity. Immunological progress. 2014 (3^rd edition); 553-574.