研究方向：

尽管过去的十几年全球在艾滋病的预防和控制方面取得了很大的成就，但仍缺乏可以根治的特效药物和有效预防疫苗。HIV/AIDS仍然是一个重大的全球公共卫生挑战。本课题组近年来关注点有：

1) HIV的感染免疫学研究

2) COVID-19的药物性肝损伤研究

在研科研课题：

1) 主持2021年国家自然科学基金面上项目（批准号：82072277）（2021-2024）

2) 主持2021年北京市自然基金面上专项（批准号：M21021）（2021-2023）

3) “十三五” 科技重大专项课题“艾滋病疫苗研究”的任务负责人（2018-2021）

4) “十三五” 科技重大专项课题“艾滋病综合治疗方案的优化及推广应用研究”的任务负责人（2017-2021）

代表性论文（第一作者#，通讯作者*）：

1. Linting Lv^#, ……, Hao Zhang*, Tao Shen*. Application of single-cell real-time imaging flow cytometry in rapid detection of pathogenic fungi in clinical liquid specimens. Methods and Applications in Fluorescence. 2021 Feb 18. doi: 10.1088/2050-6120/abe7ca.

2. Huilong Chen^#, Xinjie Li^#, ……, Tao Shen*. Cardiac Troponin I Association with Critical illness and Death Risk in 726 Seriously Ill COVID-19 Patients: A Retrospective Cohort Study. International journal of Medical Sciences. 2021; 18(6): 1474-1483.

3. Xinjie Li^#, Tuohutaerbieke Marmar^#, ……, Tao Shen*, Dong Xu*. Predictive indicators of severe COVID-19 independent of comorbidities and advanced age: a nested case-control study. Epidemiology and Infection, 2020 Oct 14;148: e255.

4. Tao Shen^#, Yingxia Liu^#, Jia Shang^#, ……, Yimin Mao*, Chengwei Chen*. Incidence and etiology of drug-induced liver injury in mainland China. Gastroenterology. 2019; 156(8): 2230-2241.

5. Zhe Xie^#, Jiajia Zheng^#, ……, Tao Shen*. Deficient IL-2 produced by activated CD56+ T cells contributed to impaired NK cell-mediated ADCC function in chronic HIV-1 infection. Frontiers in Immunology. 2019 Jul 16;10:1647

6. Xinyi Pei^#, Xueying Fan^#, ……, Tao Shen*. Low frequency, weak MCP-1 secretion and exhausted immune status of peripheral monocytes were associated with progression of severe enterovirus A71-infected hand, foot, and mouth disease. Clinical & Experimental Immunology. 2019 Jun; 196(3): 353-363.

7. Linling Lv^#, Yuantao Li^#,……, Tao Shen*. HCV coinfection aggravated the decrease of platelet counts, but not mean platelet volume in chronic HIV-infected patients. Scientific Reports. 2018, 8: 17497.

8. Zhe Xie, ……, Tao Shen*. Polymorphisms in the Th17 cell-related RORC gene are associated with spontaneous clearance of HCV in Chinese women. BMC Infectious Diseases. 2018, 18:254.

9. Lu Long^#, Manxue Jia^#, ……, Tao Shen*. Non-neutralizing epitopes induce robust hepatitis C virus (HCV) - specific antibody- dependent CD56+ natural killer cell responses in chronic HCV-infected patients. Clinical & Experimental Immunology. 2017 Jul; 189(1): 92-102.

10. Liang Hua^#, Xie Zhe^#, Shen Tao*. Monocyte activation and cardiovascular disease in HIV infection. Cellular & Molecular Immunology. 2017 Dec;14(12):960-962.

11. Xueying Fan^#, Liyan Zhu^#, ……, Tao Shen* Antibody-dependent CD56+ T cell responses are functionally impaired in long-term HIV-1 infection. Retrovirology. 2016 Nov 4; 13(1):76.

12. Xiangbo Huang^#, Hua Liang^#, ……,Tao Shen*. Liver damage in patients with HCV/HIV coinfection is linked to HIV-related oxidative stress. Oxidative Medicine and Cellular Longevity. 2016, doi:10.1155/2016/8142431.

13. Bangning Cheng^#, Yulian Jin^#, ……, Tao Shen*. Serum cholinesterase: a potential assistant biomarker for hand, foot, and mouth disease caused by enterovirus 71 infection. Infectious Diseases of Poverty. 2016; 5:27.

14. Xiangbo Huang^#, Zhongping Deng^#, ……,Tao Shen* and Fengmin Lu. Traceability, reproducibility and clinical evaluation of sansure realtime HCV RNA assay. BMC Infectious Diseases. 2016, 16:47.

15. Wang Jie^#, Shen Tao^#, Huang Xiangbo^#,……, Fengmin Lu*. Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound. Journal of Hepatology. 2016; 65(4): 700-710.

16. Jian Gao^#, Zhaojun Duan^#, ……, Tao Shen* and Fengmin Lu*. Failure recovery of circulating NKG2D⁺CD56^dim NK cells in HBV-associated hepatocellular carcinoma after hepatectomy predicts early recurrence. OncoImmunology. 2015, 4:11,e1048061.

17. Zhaojun Duan^#, Jian Gao^#, ……, Tao Shen* and Fengmin Lu*. Phenotype and function of CXCR5+CD45RA-CD4+ T cells were altered in HBV-related hepatocellular carcinoma and elevated serum CXCL13 predicted better prognosis. Oncotarget. 2015, 6(42): 44239-44253.

18. Hua Liang, ……, Tao Shen*, Yiming Shao*. Higher level of circulating monocyte-platelet aggregates correlated with viremia and increased sCD163 level in HIV-1 infection. Cellular & Molecular Immunology, 2015; 12(4): 435-443.

19. Lu Long, Tao Shen*, ……, Fengmin Lu*. Effectiveness of HCV core antigen and RNA quantification in HCV-infected and HCV/HIV-1-coinfected patients. BMC Infectious Diseases. 2014; 14:577.

20. Zhaojun Duan^#, Xiangmei Chen^#, ……, Tao Shen*, Fengmin Lu*. Genetic polymorphisms of CXCR5 and CXCL13 are associated with non-responsiveness to the hepatitis B vaccine. Vaccine. 2014; 32 (41):5316-22.

21. Yuan Liu^#, Quanjun Lv^#, ……, Tao Shen*, Fengmin Lu. Coinfection with HIV-1 alleviates iron accumulation in patients with chronic hepatitis C virus infection. PLoS One. 2014; 9(6): e98039

22. Jiajia Zheng^#, Hua Liang^#,……, Tao Shen*, Fengmin Lu*. Unbalanced PD-1/CD86 ratio on CD14++CD16+ monocyte was correlated with HCV viremia during chronic HCV infection. Cellular & Molecular Immunology. 2014;11(3):294-304.

23. Yuan Liu, Tao Shen*, ……, Fengmin Lu*. HIV coinfection accelerates decay of humoral responses in spontaneous resolvers of HCV infection. Journal of Viral Hepatitis. 2014; 21(10): 690-695.

24. Chunhui Xu^#, Tao Shen^#, J……, Fengmin Lu*. Higher dN/dS ratios in the HCV core gene, but not in the E1/HVR1 gene, are associated with human immunodeficiency virus-associated immunosuppression. Archives of Virology. 2012; 157(11): 2153-2162

25. Tao Shen^#, Xiangmei Chen^#, ……, Hui Zhuang*. A higher correlation of HCV core antigen with CD4+ T cell counts compared with HCV RNA in HCV/HIV-1 coinfected patients. PLoS One. 2011; 6(8): e23550.

26. Tao Shen^#, Jiajia Zheng^#, …..., Fengmin Lu*. Characteristics and PD-1 expression of peripheral CD4⁺CD127^loCD25^hiFoxP3⁺ Treg cells in chronic HCV infected-patients. Virology Journal. 2011; 8:279.

27. Tao Shen^#, ……, Fengmin Lu*, Hui Zhuang*. PD-1 expression on peripheral CD8+ TEM/TEMRA subsets closely correlated with HCV viral load in chronic hepatitis C patients. Virology Journal. 2010; 7:310.

28. Tao Shen*, ……, Shuang Liu*. Distributional Characteristics of CD25 and CD127 expression on CD4+ T cell subsets in HCV chronic infection. Archives of Virology. 2010; 155(5):627-634.

29. Tao Shen*, ……, Shuang Liu*. Increased PD-L1 expression and PD-L1/CD86 ratio on dendritic cells were inversely associated with impaired dendritic cells function in HCV infection. Journal of Medical Virology. 2010; 82(7):1152-1159.

30. Tao Shen^#, ……, Booki Min*. T cell-derived IL-3 plays key role in parasite infection-induced basophil production but is dispensable for in vivo basophil survival. International Immunology. 2008; 20(9):1201-1209.

31. Tao Shen^#, ……,Yiming Shao*. Amino acid mutations of the infectious clone from Chinese EIAV attenuated vaccine resulted in reversion of virulence. Vaccine. 2006; 24(6): 738-749.

申请专利：

1. 沈弢，张浩. 发明专利：一种富集病原菌的平衡液及其制备方法和应用。受理号：2020101033949。申请时间：2020-2-19。

2. 沈弢，张浩，吕琳婷. 发明专利：一种细菌检测试剂盒及其应用。受理号：2020101033953。申请时间：2020-2-19。

3. 沈弢，张浩，吕琳婷. 发明专利：一种真菌检测试剂盒及其应用。受理号：2020101034119。申请时间：2020-2-19。

4. 沈弢，张浩，吕琳婷，郑佳佳，许强，屠静，王誉雅. 发明专利：一种真菌感染检测试剂盒及其应用。受理号：201910315798。申请时间：2019-4-18。

5. 沈弢，张浩，吕琳婷，郑佳佳，许强，屠静，王誉雅. 发明专利：一种真菌检测方法。受理号：201911109885。申请时间：2019-11-12。

6. 吕琳婷，张浩，沈弢. 实用新型专利：一种微生物富集磁座。受理号：201921862893。申请时间：2019-10-31。

7. 吕琳婷，张浩，沈弢. 外观设计专利：微生物富集磁座。受理号：201930596476。申请时间：2019-10-31。

个人其他信息：

1994年本科毕业于蚌埠医学院，2002年硕士毕业于卫生部武汉生物制品研究所，2005年博士毕业于中国疾病预防控制中心性病艾滋病预防控制中心。2006年分别在美国克利夫兰临床基金会医院（The Cleveland Clinic）和凯斯西储大学医学院（Case Western Reserve University School of Medicine）从事博士后研究。北京微生物学会第十一届理事会理事，《中华微生物学和免疫学杂志》和《中国输血杂志》编委。参编多部《医学微生物学》相关本专科教材。担任多个国际学术期刊和多家中文学术期刊的同行评审专家。