魏雅槟 博士

北京大学中国药物依赖性研究所

副研究员，博士生导师

联系方式：北京市海淀区学院路38号，邮编 100191

Tel: 82802456

Email：yabin.wei@bjmu.edu.cn; yabin.wei@hotmail.com

研究方向：

（1） 抑郁症、躁狂抑郁双相情感障碍的发病与治疗机制研究

（2） 儿童孤独症等神经发育障碍性疾病的发病与治疗机制研究

（3） 神经精神疾病的药物基因组学

（4） 体外诱导干细胞、3D脑类胚体模型在神经精神疾病中的应用

教育背景

2005 - 2010 js3845金沙线路 医学学士

2011 - 2015 Karolinska Institutet 博士

研究经历

2016 - 2017 Scripps Research Institute 博士后

2017 - 2019 University of California San Diego 博士后

2020 - 现在 js3845金沙线路 副研究员

研究成果

美国试行专利：62/757,686: Method to predict response to neuropsychiatric drugs using variation in the serotonin 7 receptor (HTR7) gene

代表论文

1）Maria Scherma, Johanna S. Qvist, Arun Asok, Shao-shan C. Huang, Paolo Masia, Matteo Deidda, Ya B. Wei, Rajesh K. Soni, Walter Fratta, Paola Fadda, Eric R. Kandel, Denise B. Kandel, and Philippe A. Melas. Cannabinoid exposure in rat adolescence reprograms the initial behavioral, molecular, and epigenetic response to cocaine. Proc Natl Acad Sci U S A. 2020 May 5;117(18):9991-10002.

2）Liu JJ*, Wei YB*, Strawbridge R, Bao Y, Chang S, Shi L, Que J, Gadad BS, Trivedi MH, Kelsoe JR, Lu L. Peripheral cytokine levels and response to antidepressant treatment in depression: a systematic review and meta-analysis. Mol Psychiatry. 2019 Aug 19. doi: 10.1038/s41380-019-0474-5. *Shared first authorship.

3）Wei YB, McCarthy M, Ren H, Carrillo-Roa T, Shekhtman T, DeModena A, Liu JJ, Leckband S, Mors O, Rietschel M, Henigsberg N, Cattaneo A, Binder EB, Aitchison KJ, Keloe JR. A functional variant in the serotonin receptor 7 gene (HTR7), rs7905446, is associated with good response to SSRIs in bipolar and unipolar depression. Mol Psychiatry. 2019 Mar 15.

4）Liu JJ, Wei YB, Forsell Y, Lavebratt C. Stress, depressive status and telomere length: Does social interaction and coping strategy play a mediating role? J Affect Disord. 2017 Nov;222:138-145.

5）Wei YB, Liu JJ, Åberg E, Brené S, Wegener G, Mathé AA, Lavebratt C. Elevation of Il6 is associated with disturbed let-7 biogenesis in a genetic model of depression. Transl Psychiatry. 2016 Aug 16;6:e869.

6）Wei YB, Melas PA, Villaescusa JC, Liu JJ, Xu N, Christiansen SH, Elbrønd-Bek H, Woldbye DP, Wegener G, Mathé AA, Lavebratt C. MicroRNA 101b is downregulated in the prefrontal cortex of a genetic model of depression and targets the glutamate transporter SLC1A1 (EAAT3) in vitro. Int J Neuropsychopharmacol. 2016 Aug 9. pii: pyw069.

7）Wei YB, Martinsson L, Liu JJ, Forsell Y, Schalling M, Backlund L, Lavebratt C. hTERT genetic variation in depression. J Affect Disord. 2015 Sep 16;189:62-69.

8）Wei YB, Backlund L, Wegener G, Mathé AA, Lavebratt C. Telomerase dysregulation in the hippocampus of a rat model of depression. Normalization by lithium. Int J Neuropsychopharmacol. 2015 Jan 24. pii: pyv002. doi: 10.1093/ijnp/pyv002. PMID: 25618407.

9）Wei YB, Melas PA, Wegener G, Mathé AA, Lavebratt C. Antidepressant-Like Effect of Sodium Butyrate is Associated with an Increase in TET1 and in 5-Hydroxymethylation Levels in the Bdnf Gene. Int J Neuropsychopharmacol. 2014 Oct 31;18(2). PMID: 25618518.

10）Martinsson L*, Wei YB*, Xu D, Melas PA, Mathé AA, Schalling M, Lavebratt C, Backlund L. Long-term lithium treatment in bipolar disorder is associated with longer leukocyte telomeres. Transl Psychiatry. 2013 May 21; 3:e261. *Shared first authorship.